U.K. Chancellor Rishi Sunak and Health Secretary Sajid Javid Resign From Boris Johnson’s Government

LONDON—British Prime Minister Boris Johnson suffered a potentially fatal political blow Tuesday as his treasury chief and health secretary resigned from his cabinet, saying they no longer had confidence in his leadership.

The coordinated departures of Chancellor of the Exchequer Rishi Sunak and Health Secretary Sajid Javid, two of Mr. Johnson’s most senior ministers, represent a severe challenge to his ability to hold on to power.